Peptide Publications Archive
Showing items in Chemical Biology · Clear filter
Steering Cysteine Chemistry
Tsai Lab
Most reagents that target N-terminal cysteine consume both the amine and thiol, locking the ligation site into an inert heterocycle. A new steric-control strategy forces …
Labeling Serine Selectively
Chen Lab
Serine and threonine hydroxyl groups are among the most difficult side chains to modify selectively in complex peptides, yet they govern phosphorylation, glycosylation, and enzyme …
Chaperone Orientation Rules
Gierasch Lab
Three closely related Hsp70 molecular chaperones grip the same model peptides in strikingly different orientations: bacterial DnaK shows no directional preference, human Hsc70 leans toward …
Amide Proteome Mapped
Raj Lab
A palladium-mediated dehydration reaction converts asparagine and glutamine amides to nitriles, opening nearly 9% of the human proteome to chemoproteomic interrogation for the first time...
Silent Residues, Activated
Raj Lab
Asparagine and glutamine make up over 8% of the human proteome yet resist chemical modification — until now, when a palladium-mediated strategy converts their amide …
Light-Driven Ligation
Taylor Lab
A fully organic photosensitizer pair labels proteins inside living cells with 93% selectivity for tryptophan, reaching nuclear compartments without any metal catalyst
Sugar's Hidden Hand
Pratt Lab
A single O-GlcNAc on α-synuclein forces a distinct amyloid strain that spreads far less pathology in neurons and mouse models than the unmodified protein
Sweet Reprogramming of the Ribosome
Payne Group
A dipeptide reprogramming trick lets ribosomes build glycopeptide libraries for the first time, yielding potent P-selectin inhibitors and a monomeric LYTAC alternative
Switching Max On
Jbara Lab
A photocaged Max transcription factor sits dark and silent until a flash of UV light removes two chemical masks and restores full DNA-binding activity within …
Backbone Sensitivity
Cryle Lab
Researchers supervised by Professors Julien Tailhades and Max J. Cryle from Monash University, Australia, published in ACS Chemical Biology, have developed a chemoenzymatic strategy …
NMR Double Agent
Liu Lab
Researchers in the Liu Group at the Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, published in J. Am. Chem. Soc. …
Unwinding RNA Delivery
Dulin Lab
Researchers in the Dulin Group at Vrije Universiteit Amsterdam investigated the biophysical effects of two peptides derived from the tomato aspermy virus 2b, TAV2b, protein …
Cooperativity Unlocked
Waters Lab
Christopher Travis, and colleagues in Marcey Waters' laboratory at the University of North Carolina, published in Biochemistry, devised an elegant strategy to probe why …
Quantifying S-Acylation
Thinon Group
Researchers in the Emmanuelle Thinon Group at the University of Bordeaux, published in ACS Chemical Biology as part of the special issue "Lipids and Lipidation," …
Nitrogen Walks
Huang/Xiao Labs
Noncanonical amino acids have become indispensable tools in chemical biology and drug discovery. By introducing side chains that nature never encoded, researchers can endow peptides …
Catching Lanthanides
Zeymer Lab
Lanthanide ions offer an extraordinary toolkit for biomolecular engineering. Their long-lived luminescence enables sensitive detection, their paramagnetism provides NMR structural probes, their strong anomalous X-ray …
Guided Precision
Waser Lab
Cysteine residues attract chemical attention. Their nucleophilic thiol groups react readily with electrophiles, making them popular handles for attaching drugs, fluorophores, and other payloads to …
Borrowed Machinery
Xu Lab
N-myristoylation is a common posttranslational modification in which the enzyme N-myristoyltransferase, NMT, attaches a 14-carbon fatty acid to an N-terminal glycine residue. This lipid anchor …
Optimizing Peptide Switches
Maly Lab
Chemically-controlled genetic tools allow researchers to switch cellular processes on or off with small molecules, offering precise temporal and dose-dependent control. While chemically-inducible dimerization systems …
Taming Arginine
Raj Lab
Selective modification of amino acid side chains has become a central strategy for expanding peptide function beyond the limits of ribosomal chemistry. Yet one residue …
Iodo Quantification
Lilienkampf Lab
In work published in ACS Chemical Biology, David J. Clarke, Annamaria Lilienkampf, and collaborators from the University of Edinburgh, introduce an iodo based labeling strategy …
Dilp Divergence
Bland Lab
Insulin-like peptides orchestrate how animals apportion nutrients between storage and growth, yet distinct ligands may encode different cues even when signaling through a single receptor. …
Affinity Landscapes
Bussemaker Lab
A collaborative study from the Bussemaker and Shah Groups at Columbia University, published in Protein Science, establishes an integrated experimental–computational framework, built on massively …
Serine Switch
Diao Lab
Published in the Journal of the American Chemical Society, work by first author Zhenyan Guo in the Diao Lab at the New York University, …